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Cerebral blood flow and plasma hypoxanthine in relation to surfactant treatment
Author(s) -
Bell AH,
Skov L,
Lundstrøm KE,
Saugstad OD,
Greisen G
Publication year - 1994
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1994.tb13169.x
Subject(s) - medicine , cerebral blood flow , anesthesia , electroencephalography , pulmonary surfactant , depression (economics) , blood flow , blood pressure , cardiology , chemistry , biochemistry , psychiatry , economics , macroeconomics
We have previously reported reduction in EEG activity in preterm babies after tracheal instillation of Curosurf. To elucidate the cause of EEG depression, we have examined cerebral blood flow (CFB), amplitude‐integrated EEG (aEEG), mean arterial blood pressure (MABP) and plasma hypoxanthine (Hx) concentration in a group of preterm babies before and immediately after administration of surfactant. No change occurred in CBF immediately after surfactant treatment despite a significant decrease in MABP. At 60 min after surfactant administration, a significant reduction in CBF occurred ( p < 0.05). However, when CBF values were corrected for changes in PaCO 2 , no reduction in CBF was observed. Mean plasma Hx concentration was 11.6 (SD 7.3) μmol/l before surfactant therapy, which decreased significantly to 8.1 (5.8) μmol/l ( p < 0.05) 15–30 min after treatment. No correlations were found between plasma Hx concentration and FiO 2 , a/A pO 2 , PaCO 2 , SaO 2 , arterial blood pressure, CBF or the degree of EEG depression. This study indicates that EEG depression observed after surfactant instillation is not caused by cerebral ischemia.