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Aplasia cutis congenita of the scalp in an infant exposed to valproic acid in utero
Author(s) -
Hubert Armelle,
Bonneau Dominique,
Couet Dominique,
Berthier Michel,
Oriot Denis,
Larregue Marc
Publication year - 1994
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1994.tb13143.x
Subject(s) - aplasia cutis congenita , medicine , valproic acid , scalp , in utero , pregnancy , anticonvulsant , dermatology , pediatrics , fetus , epilepsy , psychiatry , biology , genetics
We report a newborn with isolated aplasia cutis congenita of the scalp whose mother was treated with valproic acid during pregnancy. Aplasia cutis congenita has been described in infants exposed in utero to antithyroid drugs, but has not been related to other tetratogenic agents. Fetal exposure to valproic acid is known to increase the risks of spina bifida and other midline defects. Interestingly, aplasia cutis congenita of the scalp is regarded as a cutaneous marker for neural dysraphism. However, this defect of the scalp and valproic acid intake during pregnancy may be a random association and similar observations are needed to suggest causality.