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Congenital varicella syndrome: studies of the virus‐specific humoral and cell‐mediated immune responses
Author(s) -
Schuster Volker,
Hofmann Gerhard,
Pannenbecker Jürgen,
Kreth Hans Wolfgang
Publication year - 1994
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1994.tb13141.x
Subject(s) - medicine , immune system , immunology , varicella zoster virus , antibody , virus , humoral immunity , pregnancy , fetus , virology , cellular immunity , biology , genetics
We describe a three‐year‐old boy with congenital varicella syndrome. Persistent IgG antibodies to varicella‐zoster virus (VZV) were detected in the child's sera for a period of more than three years. Immunological studies performed at three months and at three years of age showed a VZV‐specific cellular immune response. The results suggest that intrauterine VZV infections in early pregnancy can induce adequate humoral and cellular immune reactions in the infected foetus.