Premium
Can renal handling of phosphate predict response to growth hormone therapy in normal variant short children by short‐term treatment?
Author(s) -
Tomoeda Shinichi,
Nishiyama Soroku,
Nakamura Toshiro,
Matsuda Ichiro
Publication year - 1994
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1994.tb13129.x
Subject(s) - medicine , renal function , human growth hormone , endocrinology , reabsorption , hormone , growth hormone , phosphate , growth velocity , growth hormone treatment , hormone therapy , kidney , urology , biochemistry , biology , cancer , breast cancer
We investigated if renal handling of phosphate could predict height velocity in 28 normal variant short children (16 boys and 12 girls). Before and after human growth hormone was given for four consecutive days, the ratio of maximum tubular reabsorption rate for phosphorus to glomerular filtration rate (TmP/GFR) was calculated. Based on increments in TmP/GFR (4TmP/GFR) with growth hormone administration, the patients were divided into two groups; children in whom the levels of ΔTmPiGFR were 0.8 mg/dl GF or more (group A, n = 7) and those with levels less than 0.8 mg/dl GF (group B, n = 21). All children in group A and some in group B ( n = 9) were injected with 0.5 IU/kg/week of recombinant human growth hormone for over one year. Height velocity during therapy was significantly greater in treated children in group A than in group B and was similar among treated (n = 9) and untreated ( n = 12) children in group B. The present study suggests that change in renal handling of phosphate during short‐term growth hormone administration can serve to select normal variant short children who will respond well to growth hormone therapy.