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Pattern and antibiotic susceptibility of bacteria in pyogenic meningitis in a children's emergency room population in Maiduguri, Nigeria, 1988–1992
Author(s) -
Akpede George O,
Adeyemi Olumuyiwa,
Abba Aminu A,
Sykes Roger M
Publication year - 1994
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1994.tb13126.x
Subject(s) - medicine , bacterial meningitis , meningitis , antibiotics , population , emergency department , pediatrics , bacteria , microbiology and biotechnology , environmental health , psychiatry , genetics , biology
From January 1988 to November 1992, 107 (3.5%) of 3074 postneonatal children admitted to the Children's Emergency Room, University of Maiduguri Tcaching Hospital, Nigeria. had sporadic pyogenic meningitis; 66 (61.7%) were aged ≤12 months. Streptococcus pneunioniue. Neisseria meningitidis and Huemophilus influenae together were responsiblc for 77.3% (58) of 75 culture‐proven cases, 13.4% (10) had Enterobactcriaceae, 5.3%) (4) had Stuphylococcus aureus and 4% (3) untyped α‐haemolytic streptococci. Fifty percent of 62 bacteria were resistant to ampicillin, 47.2% of 36 to penicillin and 10.7% of 56 to chloramphenicol; none of 21 bacteria was simultaneously resistant to all three antibiotics. Up until 1992. we havc encountered treatment failure with a regimen containing chloramphenicol in only 2 of 53 patients; the 2 patients had coliform meningitis. Nun‐meningococcal bacteria are an important cause of sporadic pyogenic meningitis in sub‐Saharan Nigeria and chloramphenicol is the most appropriate initial drug of choice at the present time for the management of sporadic meningitis.