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Free‐radical‐induced lipid peroxidation during the early neonatal period
Author(s) -
Varsila Eeva,
Hallman Mikko,
Andersson Sture
Publication year - 1994
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1994.tb13120.x
Subject(s) - medicine , lipid peroxidation , period (music) , physiology , oxidative stress , physics , acoustics
The effect of gestational age on postnatal free‐radical‐mediated lipid peroxidation was studied in 19 term (gestational age 37–42 weeks) and 21 healthy preterm (gestational age 31–36 weeks) infants by measurement of expired ethane and pentane during the first 7 days of life. Ethane (11.9 versus 5.7 pmol/kg/min; p = 0.0001) and pentane (11.4 versus 7.5 pmol/kg/min; p = 0.01) were significantly higher in preterm than in term infants. Correlations were found between gestational age and ethane ( r = 0.60, p = 0.0001) for days 1–7 and pentane ( r = 0.54, p = 0.0003) for days 3–7; and between birth weight and ethane ( r = 0.58, p = 0.0001) and pentane (r = 0.55, p = 0.0003). These results indicate that during the postnatal period, immaturity is a major factor determining the rate of free‐radial‐mediated lipid peroxidation.