Premium
Undetectable levels of serum FSH immunoactivity and bioactivity in girls with sexual precocity due to ovarian cysts
Author(s) -
Low LCK,
Wang C,
Leung A,
Leong LY
Publication year - 1994
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1994.tb13093.x
Subject(s) - medicine , medroxyprogesterone acetate , endocrinology , aromatase , endocrine system , precocious puberty , basal (medicine) , stimulation , follicle stimulating hormone , estrogen , hormone , luteinizing hormone , insulin , cancer , breast cancer
Low LCK, Wang C, Leung A, Leong LY. Undetectable levels of serum FSH immunoactivity and bioactivity in girls with sexual precocity due to ovarian cysts. Acta Paediatr 1994;83:623–6. Stockholm. ISSN 0803–5253 Clinical presentation and endocrine investigations in five girls with precocious sexual development due to ovarian cysts are presented. These girls had pubertal oestradiol and suppressed gonadotrophin responsiveness to LHRH stimulation. FSH bioactivity as measured by the rat aromatase assay was undetectable in basal and LHRH‐stimulated serum samples but our results cannot exclude the possibility of the presence of a species‐specific follicle stimulating factor in these patients. IM injection of depot medroxyprogesterone acetate controlled pubertal development in two children.