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Abnormalities of lung volume at follow‐up after antenatal rhesus iso‐immunization
Author(s) -
Greenough A,
Yuksel B,
Nicolaides KH
Publication year - 1994
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1994.tb13066.x
Subject(s) - medicine , lung , gestational age , lung volumes , pregnancy , gastroenterology , anesthesia , surgery , genetics , biology
Greenough A, Yuksel B, Nicolaides KH. Abnormalities of lung volume at follow‐up after antenatal rhesus iso‐immunization. Acta Pzdiatr 1994;83:498–500. Stockholm. ISSN 0803 5253 Rhesus iso‐immunization is associated with fatal pulmonary hypoplasia. We have examined the hypothesis that abnormalities of lung volume, as an index of lung growth, may also be found in survivors. At a median age of nine months, lung volume was assessed by measurement of functional residual capacity in 23 patients affected antenatally by rhesus iso‐immunization. Seventeen of the patients had required at least one intrauterine transfusion. Five patients (group A) had an FRC < 24 ml/kg (mcdian 21 ml/kg, range 19–22 ml/kg) and the other 18 (group B) an FRC 24 ml/kg (median 27 ml/kg, range 24–36 ml/kg) ( p < 0.01). The only significant difference between these two groups was the timing of the first foetal blood sampling and intrauterine transfusion, being a median of 22 weeks (range 20–23 weeks) in group A and 30 weeks (range 17–36 weeks) in group B ( p< 0.01). 0