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Immunosuppression after measles vaccination
Author(s) -
Smedman Lars,
Joki Annalena,
Silva Augusto Paulo Jost,
TroyeBlomberg Marita,
Aronsson Bernice,
Perlmann Peter
Publication year - 1994
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1994.tb13043.x
Subject(s) - medicine , measles , vaccination , immunology , toxoid , immunosuppression , tetanus , immune system , measles vaccine , concanavalin a , measles virus , lymphoproliferative response , lymphocyte , virology , biology , peripheral blood mononuclear cell , biochemistry , in vitro
The influence of conventional live attenuated measles vaccine on cellular immune responsiveness was investigated in Sweden and Guinea‐Bissau. Sixteen children in a residential area in Bissau and 16 living in southern Stockholm were examined before and 8–10 days after vaccination. Lymphoproliferation was measured to concanavalin A (con‐A), PPD and tetanus toxoid (TT) using a whole‐blood 3 H‐thymidine incorporation assay. Stimulation indices were significantly lower after vaccination than before, in the case of con‐A ( p = 0.03) and TT ( p = 0.01) in the Guinean children and in the case of PPD ( p = 0.009) and TT ( p = 0.03) in the Swedish children. Stimulation of lymphocytes from measles‐immune children with measles antigens resulted in weak lymphoproliferative responses. These observations may be relevant to the increased mortality found in children immunized with high‐titre measles vaccines, as compared to controls, in recent studies. The study confirms the applicability and usefulness under field conditions of the whole blood version of the thymidine incorporation assay.