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Helicobacter pylori infection in children with recurrent abdominal pain
Author(s) -
Wewer V,
Christiansen KM,
Andersen LP,
Henriksen FW,
Hansen JP Hart,
Tvede M,
Krasilnikoff PA
Publication year - 1994
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1994.tb13015.x
Subject(s) - medicine , helicobacter pylori , abdominal pain , serology , gastroenterology , metronidazole , endoscopy , pathological , concomitant , histology , penicillin , antibiotics , immunology , antibody , microbiology and biotechnology , biology
Helicobacter pylori was cultured and Helicobacter‐like organisms (HLO) were seen in 6 (16%) of 37 children with recurrent abdominal pain. Five children had concomitant histological inflammation, but none had endoscopic changes. All 6 children demonstrated positive serology. Compared with the total group, they were more often from developing countries, larger families and lower Social groups. Treatment with phenoxymethyl penicillin and colloidal bismuth subcitrate did not result in side effects or elevated serum levels of serum bismuth. Three children demonstrated metronidazole‐resistant strains and the treatment of these children remained an unsolved problem. Among the 31 H. pylori/ HLO negative children 8 (26%) demonstrated histological changes, 5 (16%) endoscopic changes and 11 (35%) had positive serology. In conclusion, pathological findings at upper gastrointestinal endoscopy are common in children with recurrent abdominal pain. Because of disconcordance between endoscopy, histology and culture, we recommend that biopsies should always be taken to clarify the diagnosis.