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Ferritin levels in pediatric HIV‐1 infection
Author(s) -
Ellaurie M,
Rubinstein A
Publication year - 1994
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1994.tb12978.x
Subject(s) - medicine , ferritin , immunology , disease , serum ferritin , inflammation , acute phase protein , human immunodeficiency virus (hiv) , immunopathology
Ferritin is an acute phase protein which is often elevated in acute and chronic inflammation, as well as in neoplastic disease. In adults with human immunodeficiency virus (HIV) infection, elevated serum ferritin levels indicate advanced or progressive disease. In the present study, ferritin levels were evaluated in 88 HIV‐infected children. Ferritin levels greater than 100ng/ml were found in 93% of patients with advanced disease. Increasing levels always accompanied or closely preceded rapid disease progression. Serum ferritin levels may prove to be a useful marker to monitor disease progression and therapeutic efficacy in HIV‐infected children.