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Effect of sustained inflations applied directly after cord clamping on lung function in premature newborn lambs
Author(s) -
KlöppingKetelaars WAA,
Maertzdorf WJ,
Blanco CE
Publication year - 1994
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1994.tb12974.x
Subject(s) - medicine , anesthesia , gestational age , oxygenation , pneumothorax , oxygenation index , lung volumes , cord , lung , expiration , airway , pulmonary compliance , surgery , respiratory system , pregnancy , genetics , biology
We studied the possibility of improving lung volume and therefore clinical outcome in premature newborn lambs by increasing the inspiratory volumes during the first minute after birth. Sixteen lambs from eight were delivered by hysterotomy after 130–131 days' gestation. In eight lambs the lungs were inflated with a bag with a sustained inspiratory inflation (SI) of 5 s and expiratory time of 5 s during the first four inflations after cord clamping and then mechanically ventilated. Their siblings did not receive SI and served as a control group. At 8 h postnatally, the SI and control groups showed the following results (mean ± SEM): mean airway pressure 14.8 ± 1.8 cmH 2 O versus 11.9 ± 1.1 cmH 2 O, PaO 2 41.5 ± 7.3 kPa versus 31.3 ± 7.7kPa, alveolar‐arterial oxygen gradient 359 ± 55 mmHg versus 437 ± 58 mmHg. Clinical course, incidence of pneumothorax, oxygenation index, total static compliance, parenchymal‐alveolar air area ratio or mortality rate were not different. There was no significant difference between the two groups at this time or at any other time during the experiments.