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Decreased growth hormone response to dexamethasone stimulation test in obese children
Author(s) -
Pineda J,
Dieguez C,
Casanueva FF,
Martul P
Publication year - 1994
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1994.tb12963.x
Subject(s) - medicine , dexamethasone , stimulation , growth hormone , endocrinology , test (biology) , hormone , paleontology , biology
Pineda J, Dieguez C, Casanueva FF, Martul P. Decreased growth hormone response to dexamethasone stimulation test in obese children. Acta Pædiatr 1994;83:103–5. Stockholm. ISSN 0803–5253 Acute administration of glucocorticoids is a recently described stimulus for growth hormone secretion. The aim of the present study was the assessment of dexamethasone‐induced growth hormone secretion in obese children. Dexamethasone iv tests were carried out in 14 normal control and 8 obese children. Growth hormone was measured by radioimmunoassay up to 5 h after dexamethasone administration. Dexamethasone elicited clear growth hormone secretion in normal children (mean peak 12.3 ± 1.6; area under the curve 682.3 ± 74.3). In the obese children, dexamethasone induced a slight but significant ( p <0.01) increase in growth hormone over basal values. However, the growth hormone response in this group was significantly lower than in the normal controls, when comparing both mean peak (5.5 ± 2.3, mean±SEM) ( p <0.01) and area under the curve (306.8±44.5) ( p <0.001).