Premium
Inhibitor to factor V after exposure to fibrin sealant during cardiac surgery in a two‐year‐old child
Author(s) -
Muntean W,
Zenz W,
Finding K,
Zobel G,
Beitzke A
Publication year - 1994
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1994.tb12958.x
Subject(s) - fibrin , medicine , sealant , thrombin , cardiac surgery , anesthesia , factor v , surgery , immunology , platelet , thrombosis , chemistry , organic chemistry
Muntean W, Zenz W, Finding K, Zobel G, Beitzke A. Inhibitor to factor V after exposure to fibrin sealant during cardiac surgery in a two‐year‐old child. Acta Prediatr 1994;83:84–7. Stockholm. ISSN 0803–5253 A two‐year‐old infant developed an inhibitor to factor V after cardiac surgery, with application of fibrin sealant containing bovine thrombin. Investigation of this inhibitor by means of inhibition experiments and immunoblot analysis revealed that the inhibitor reacted strongly with bovine, but only weakly with human factor V. Plasmapheresis proved effective in increasing factor V levels. This patient provides further evidence that exposure to topical thrombin preparations may lead to the development of inhibitors in the postoperative period that may cause bleeding complications.