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Lipoprotein alterations in children with bacterial meningitis
Author(s) -
Henter JanInge,
Carlson Lars A.,
Hansson Mona,
NilssonEhle Peter,
Örtqvist Eva
Publication year - 1993
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1993.tb18043.x
Subject(s) - hypertriglyceridemia , medicine , cholesterol , triglyceride , endocrinology , lipoprotein , high density lipoprotein , lipoprotein lipase , adipose tissue
Abnormalities in serum lipids, including hypertriglycerideinia, are common during infectious disorders. However, the lipoprotein pattern during infections, particularly in children, has been investigated to only a limited extent. We have monitored alterations in serum lipoproteins in eight children with a severe baclcrial infcction (meningitis) by a quantitating method measuring cholesterol and triglyccrides in each major class. The levels of triglyccrides in serum and in low‐density lipoproteins were markedly elevated during the infection, whereas the amount of cholesterol in high‐density lipoprotcins was decreased. The cholesterol to triglyceride ratio was decreased in low‐, as well as in high‐density lipoproteins. These lipoprotein abnormalities may, at least in part, be explained by a depressed lipolytic activity of lipoprotein lipasc, the key enzyme for removal of triglycerides in man. Serum triglycerides and the levels of cholesterol in high‐density lipoproteins, as well as the ratio between these parameters, may be used as indicators of inflammatory activity.