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Lipid peroxidation in human milk and infant formula: effect of storage, tube feeding and exposure to phototherapy
Author(s) -
ZoerenGrobben D.,
Moison RMW,
Ester WM,
Berger HM
Publication year - 1993
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1993.tb18032.x
Subject(s) - medicine , infant formula , lipid peroxidation , food science , tube (container) , pediatrics , endocrinology , oxidative stress , biology , mechanical engineering , engineering
Preformed lipid peroxidation products present in the feed may contribute to the total reactive oxygen radical load infants have to deal with and may play a role in the pathogenesis of necrotizing enterocolitis and bronchopulmonary dysplasia. In this study, the occurrence of lipid peroxidation in human milk and feeding formulas for preterm babies was evaluated in vitro. Free linoleic acid (18:2) and its hydroperoxide (18:2OOH) were measured by gas chromatography‐mass spectrometry and the concentration of 18:2OOH and the 18:2OOH/18:2 ratio were used as indices of peroxidation. In all feeds peroxidation products were present, but the proportion of peroxidized 18:2 was greater in infant formula. Storage of human milk (+4°C for four days) increased lipid peroxidation. Exposure to light during tube feeding incrcased pcroxidation in infant formula but not in human milk. Different procedures for preparation, storage and feeding may decrease the concentration of these potentially toxic peroxidized lipids in human milk and infant formula.