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Anti‐alpha‐gliadin antibodies are not predictive of celiac disease in juvenile chronic arthritis
Author(s) -
Lepore L,
Pennesi M,
Ventura A,
Torre G,
Falcini F,
Lucchesi A,
Perticarari S
Publication year - 1993
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1993.tb12756.x
Subject(s) - medicine , gliadin , antibody , intestinal permeability , arthritis , juvenile rheumatoid arthritis , immunology , sprue , rheumatoid arthritis , gluten , gastroenterology , intestinal mucosa , juvenile , disease , pathology , biology , mold , genetics
Some authors have recently reported an increased level of antigluten antibodies in rheumatoid arthritis, both in the adult and juvenile form. The real meaning of these antibodies is still unclear. We ascertained the levels of antigluten antibodies in a group of children with juvenile chronic arthritis to determine if these antibodies were linked with celiac disease and/or to increased intestinal permeability. In 18 of 53 patients (33.9%), the levels of antigluten antibodies (IgA or IgG) were higher than normal. No correlation was found between the increase in antigluten antibodies and the positive lactulose/ mannitol test, used for determining increased intestinal permeability. In all eight patients undergoing intestinal biopsy due to abnormal levels of antigluten antibodies (IgA class), intestinal mucosa was normal. In conclusion, our study shows that in patients with juvenile chronic arthritis, immunological response to gluten is neither related to celiac disease nor to increased intestinal permeability.