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Neurological manifestations of hemorrhagic colitis in the outbreak of Escherichia coli O157:H7 infection in Japan
Author(s) -
Hamano Shinichiro,
Nakanishi Youko,
Nara Takahiro,
Seki Takashi,
Ohtani Tomoko,
Oishi Tsutomu,
Joh Kosuke,
Oikawa Tsuyoshi,
Muramatsu Yasuo,
Ogawa Yoshihiro,
Akashi Shunji
Publication year - 1993
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1993.tb12721.x
Subject(s) - medicine , outbreak , vertigo , escherichia coli , nystagmus , cerebral palsy , colitis , urinary incontinence , convulsion , pediatrics , paralysis , urinary system , surgery , epilepsy , pathology , psychiatry , biochemistry , chemistry , gene
An outbreak of hemorrhagic colitis associated with Escherichia coli O157:H7 occurred in a kindergarten in Saitama, Japan from September to November, 1990. Seven patients admitted to our hospital showed neurological manifestations: generalized seizures, impaired consciousness, urinary incontinence, gaze nystagmus, phrenic nerve palsy, action tremor and vertigo. Two patients died. On the basis of the clinical courses and laboratory findings of the seven patients and postmortem findings of one case, these neurological symptoms were suspected to be induced by the verotoxin elaborated by Escherichia coli O157:H7.