Premium
Abnormal responses of common variable immunodeficiency patients’B cells to Staphylococcus aureus Cowan I and interleukin‐2
Author(s) -
Inoue Yuko,
Kondo Naomi,
Motoyoshi Fumiaki,
Inoue Ryosuke,
Orii Tadao
Publication year - 1993
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1993.tb12707.x
Subject(s) - common variable immunodeficiency , staphylococcus aureus , medicine , isotype , receptor , stimulation , intracellular , immunology , antibody , immunodeficiency , microbiology and biotechnology , immune system , biology , monoclonal antibody , genetics , bacteria
Responses of common variable immunodeficiency patients’B cells to Staphylococcus aureus Cowan I (SAC) and recombinant interleukin‐2 (rIL‐2) varied in our study T‐cell function and IL‐2 production were normal, and intrinsic B‐cell defects were suggested. Some patients showed no increase in expression of IL‐2 receptors on B cells with SAC stimulation, which may be due to impaired maturation stages. Two patients showed an increased level of B cells with IL‐2 receptors, suggesting blocked development of intracellular mechanisms. One patient may have a defect in immunoglobulin isotype switching.