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Increase in T cells bearing the gamma/delta receptor associated with lymphoproliferative disease of granular lymphocytes in an infant with intractable diarrhea
Author(s) -
Imashuku S,
Ohmizono Y,
Itoi T,
Kataoka Y,
Ikushima S,
Hibi S,
Matsumura T,
Yagi K,
KawaHa K,
Ueno Y,
Yachie A,
Miyawaki T
Publication year - 1993
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1993.tb12563.x
Subject(s) - medicine , cd8 , t cell receptor , cd3 , delta , immunology , diarrhea , t lymphocyte , t cell , pathology , antigen , immune system , engineering , aerospace engineering
A two‐year‐old infant with intractable diarrhea and lymphoproliferative disease of granular lymphocytes attributed to a persistent cytomegalovirus infection showed an increase in cells bearing the gamma/delta T‐cell receptor (TCR), which accounted for approximately 20% of total peripheral blood lymphocytes and 40% of CD3+ T cells. Of the gamma/delta TCR+ cells, two‐thirds were double negative (CD4–/CD8–) and the other one‐third CD8 positive. The majority of gamma/ delta + cells were delta TCS 1 positive. The predominance of delta TCS 1 positive cells was also confirmed on biopsy of lymphoid tissues from the colon. After improvement of watery diarrhea and malnutrition following three‐month hyperalimentation, the number of gamma/delta TCR+ cells decreased. The patient subsequently died of pneumonia at the age of 2 years and 11 months. A possible site‐specific role for the gamma/delta TCR + cells, particularly delta TCS 1 + cells, in the human intestine is discussed.