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Comparison of the effects of phenobarbitone and morphine administration on EEG activity in preterm babies
Author(s) -
Bell Angela H,
Greisen Gorm,
Pryds Ole
Publication year - 1993
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1993.tb12511.x
Subject(s) - medicine , morphine , electroencephalography , phenobarbital , anesthesia , sedative , pharmacology , psychiatry
Continuously recorded amplitude‐integrated EEG (aEEG) traces of 77 preterm babies were analysed retrospectively, to study the effect of different sedative drugs over a 24‐h period. Thirty‐seven babies were treated with phenobarbitone, 18 received morphine and 22 babies received no regular sedation. A “burstX” was defined as a discharge of integrated amplitude greater than 10 μV and maximum interburst intervals in 10‐min epochs over a 2‐h period were measured. Maximum interburst was prolonged in babies given either morphine or phenobarbitone for sedation. Administration of a single dose of diazepam for intubation had a marked additive effect on the EEG depression caused by the base sedative and prolonged the effect for 11 to 12 h after drug administration. We conclude that the effect of sedative drugs must therefore be accounted for when interpreting records of quantified EEG for 12 to 24 h after drug administration.