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Single daily doses of trimethoprim/sulphadiazine for three or 10 days in urinary tract infections
Author(s) -
Gaudreault P,
Beland M,
Girodias JB,
Thivierge RL
Publication year - 1992
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1992.tb12336.x
Subject(s) - medicine , urinary system , trimethoprim , urine , sulfadiazine , surgery , prospective cohort study , antibiotics , microbiology and biotechnology , biology
We conducted a prospective randomized study to evaluate the efficacy of a single daily dose of 4 mg/kg of trimethoprim coupled with 17.5 mg/kg of sulphadiazine for three (group 1) or 10 days (group 2) in the treatment of uncomplicated urinary tract infections in children. Forty patients (nine boys and 31 girls) aged 2.5‐18 years, presenting with a urinary tract infection were allocated to one of the two groups. Patients were seen three, 10, and 38 days after the initiation of treatment. Control urine cultures were negative in all patients at days 3 and 10. Two patients in group 1 and one patient in group 2 suffered a relapse within a month. Single doses of trimethoprim/sulphadiazine for three or 10 days are effective in the treatment of uncomplicated urinary tract infections in children.