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Atrial natriuretic peptide in the preterm infant. Lack of correlation with natriuresis and diuresis
Author(s) -
Ekblad H,
Kero P,
Vuolteenaho O,
Arjamaa O,
Korvenranta H,
Shaffer SG
Publication year - 1992
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1992.tb12158.x
Subject(s) - atrial natriuretic peptide , medicine , natriuresis , endocrinology , diuresis , radioimmunoassay , renal function , excretion , gestational age , creatinine , gestation , sodium , pregnancy , chemistry , biology , organic chemistry , genetics
We assessed the relation of atrial natriuretic peptide (ANP) to renal function on postnatal day 2 and day 5 in preterm infants. Plasma ANP concentration was measured by radioimmunoassay in two groups of preterm infants: group 1, gestational age less than 30 weeks, n =10; and group 2, gestational age 30‐34 weeks, n =11. The identity of the immunoreactivity as ANP‐28 was confirmed by HPLC. Plasma ANP was significantly higher in group 1 than in group 2 on day 2 and day 5 ( p <0.01) and ANP concentration decreased by day 5 in both groups (group 1, p <0.01; group 2, p <0.02). The results showed no correlation between plasma ANP concentration and urinary sodium excretion or creatinine clearance, which may be due to a blunted renal response to ANP, but other factors may be involved also. We conclude that preterm infants are able to release large amounts of ANP, but a high plasma ANP concentration does not correlate directly with renal regulation of sodium and water balance.