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Non‐nutritive sucking does not increase blood levels of gastrin, motilin, insulin and insulin‐like growth factor 1 in premature infants receiving enteral feedings
Author(s) -
Kanarek Keith S,
Shulman Dorothy
Publication year - 1992
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1992.tb12157.x
Subject(s) - motilin , medicine , endocrinology , gastrin , insulin , enteral administration , hormone , bolus (digestion) , parenteral nutrition , gastrointestinal hormone , peptide hormone , secretion
Non‐nutritive sucking in premature infants accelerates weight gain for unclear reasons. The effects of non‐nutritive sucking on enteral hormone secretion may augment digestion and/or absorption of nutrients. Blood concentrations of gastrin, motilin, insulin and insulin‐like growth factor‐1 were measured before and 72 h after the initiation of nasogastric feedings in 21 premature infants randomly assigned to either a non‐nutritive suckling or control group. Gastrin and motilin concentrations increased significantly after feedings in all infants (mean ± SEM) (gastrin, 4 ± 4 to 73 ± 9 pg/ml, p <0.01; motilin, 141 ± 5 to 181 ± 3 pg/ml, p <0.01) Pre‐ and post‐feed insulin concentrations were greater in the non‐nutritive sucking group receiving bolus feeds than in control infants who were bolusfed ( P <0.01). Non‐nutritive sucking in premature infants does not appear to alter blood concentrations of motilin, gastrin, insulin or insuline‐like growth factor‐1 three days after initiation of feedings. If changes in the secretion of these hormones are induced by non‐nutritive sucking, they may be at a local paracrine level.