Premium
Elevated calcitonin gene‐related peptide in polycythemic newborn infants
Author(s) -
Saggese Giuseppe,
Bertelloni Silvano,
Baroncelli Giampiero I,
Cipolloni Carlo
Publication year - 1992
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1992.tb12155.x
Subject(s) - medicine , calcitonin , calcitonin gene related peptide , endocrinology , hyperviscosity , peptide , neuropeptide , biology , blood viscosity , biochemistry , receptor
In this study, calcitonin gene‐related peptide levels were measured in cord and at 16‐36 h of extrauterine life in 43 polycythemic newborns; 20 healthy term infants were also studied as controls. Calcitonin gene‐related peptide values were significantly higher in polycythemic neonates in comparison with controls both at delivery and at 16‐36 h after birth. Five polycythemic (11.6%) infants who develop hypocalcemia had greater elevated calcitonin gene‐related peptide concentrations. Our data suggest that calcitonin gene‐related peptide may be implicated in the circulatory adaptation to extrauterine life. In polycythemic neonates, calcitonin gene‐related peptide is probably increased to compensate for blood hyperviscosity; in some cases, high calcitonin gene‐related peptide concentrations may induce hypocalcemia.