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Skin test reactivity to atypical mycobacteria among healthy Finnish preschool children vaccinated with BCG vaccine at birth
Author(s) -
Kröger L,
Katila ML,
Korppi M.,
Pietikäinen M
Publication year - 1992
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1992.tb12130.x
Subject(s) - medicine , measles , pediatrics , parotitis , vaccination , bcg vaccine , skin reaction , mumps vaccine , rubella vaccine , immunology , rubella , reactivity (psychology) , pathology , surgery , alternative medicine
Skin test reactivity to three mycobacterial sensitins ( M. avium, M. fortuitum and M. scrofulaceum ) was studied in 353 healthy children vaccinated with the BCG vaccine at birth. A significant waning of reactivity to all of the three sensitins was found to occur with increasing age. Revaccination against measles, parotitis and rubella had been given to 31 (9%) of the children, all aged > 5.5 years. They had significantly larger reactions sizes, which was contrary to what was expected. Children with atopic dermatitis ( n =19) had significantly smaller reaction sizes to the M. fortuiturn sensitin. Neither respiratory viral infections during the preceding six months nor contact with pets or farm animals had any influence on reaction sizes. The variation of sensitin reactions was large in preschool children vaccinated with the BCG vaccine at birth. The diagnostic value of sensitin reactions in preschool children needs to be elaborated in clinical studies in children with clinically demonstrable mycobacteriosis.