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Transfer of specific IgG and IgG subclasses to herpes simplex virus across the blood‐brain barrier and placenta in preterm and term newborns
Author(s) -
Osuga T,
Morishima T,
Hanada N,
Nishikawa K,
Isobe K,
Watanabe K
Publication year - 1992
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1992.tb12105.x
Subject(s) - herpes simplex virus , medicine , placenta , immunology , immunoglobulin g , virus , gestational age , antibody , virology , blood–brain barrier , pregnancy , fetus , biology , central nervous system , genetics
The kinetics of virus‐specific IgG subclasses (IgG 1‐4) among newborns and their mothers has not yet been determined. In this report, we examined anti‐herpes simplex virus IgG activities (HSV‐IgG) and its subclasses in CSF and serum of premature or term newborns without HSV infection and in the serum of their mothers using ELISA. We found that CSF/serum ratios of HSV‐IgG and IgG subclasses (IgG 1‐4) in newborns with a gestational age less than 38 weeks were higher than those of term newborns. These findings indicate that the blood‐brain barrier against HSV‐IgG and IgG subclasses is insufficient in newborns. Furthermore, we found that HSV‐IgG subclasses, which were transferred across the placenta and later transferred across the blood‐brain barrier had a tendency to be proportional to each of the maternal HSV‐IgG subclasses.