Premium
Lipoproteins in preterm and small‐for‐gestational‐age infants during the first week of life
Author(s) -
Morillas JM,
Moltó L,
Robles R,
Gil A,
SánchezPozo A
Publication year - 1992
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1992.tb12101.x
Subject(s) - small for gestational age , medicine , gestational age , very low density lipoprotein , full term , lecithin , gestation , lipoprotein , endocrinology , cholesterol , pediatrics , pregnancy , biochemistry , biology , genetics
Plasma lipoprotein levels and composition have been determined in preterm and small‐for‐gestational‐age (SGA) infants, and compared to full‐term infants, during the first week of life. Significantly lower levels of HDL and higher levels of VLDL were found in both preterm and SGA infants in comparison to full‐term healthy infants. These results suggest a low capacity to metabolize VLDL. Preterm infants showed a behaviour similar to full‐term infants with regard to the changes in lipoprotein composition. Small‐for‐gestational‐age infants showed a higher lipoprotein lipid content than preterm infants. A low ratio of cholesteryl ester to free cholesterol (CE/FC) was found in both preterm and SGA infants suggesting a reduced lecithin: cholesterol acyl transferase (LCAT) activity. In preterm infants we observed no changes in the CE/FC ratio during the first week of life, whereas in SGA infants this ratio increased after birth.