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Familial history of cardiovascular disease and blood lipid pattern in newborn infants
Author(s) -
Bellù R,
Ortisi MT,
Agostoni C,
Incerti P,
Besana R,
Riva E,
Giovannini M
Publication year - 1992
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1992.tb12072.x
Subject(s) - medicine , disease , pediatrics
The levels of atherogenic lipid fractions are higher in children with a family history of ischemic cardiovascular disease (CD). This study was designed to examine this relationship in neonates. A total of 1276 newborns were investigated; 400 cord blood samples were collected for measurement of triglycerides (TG), total cholesterol (TC), LDL cholesterol (LDL‐C) and HDL cholesterol (HDL‐C); on day 4, 1200 capillary samples were taken for TC and TG measurements. Male newborns with a positive history of CD had higher concentrations of cord blood TC ( P < 0.04) and LDL‐C ( P < 0.02). On day 4 this difference in TC was no longer detectable (LDL‐C not determined). A coronary heart disease (CHD) risk factor family history is sensitive (0.87) in predicting high cord blood concentrations of LDL‐C, the specificity being 0.46 and the positive predicting value 0.08.