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Congenital Renal Tubular Dysfunction Associated with Maternal Sniffing of Organic Solvents
Author(s) -
LINDEMANN R.
Publication year - 1991
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1991.tb11967.x
Subject(s) - sniffing , medicine , metabolic acidosis , distal renal tubular acidosis , renal tubular acidosis , acidosis , fetus , pregnancy , endocrinology , physiology , anatomy , genetics , biology
. Two cases of neonatal renal tubular dysfunction and metabolic acidosis due to maternal sniffing of a product containing toluene are reported. Both mothers had been sniffing regularly throughout their pregnancies. The infants were dysmature and had some dysmorphic features. They had hyperchloraemic acidosis and exhibited amino‐aciduria. The metabolic changes were however transient. It is suggested that the sniffing of tohene containing solvents daring pregnancy may change membrane permeability in both the proximal as well as distal renal tubules and may also enhance liver enzyme activity in the foetus.