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Does VLDL‐LDL‐Cholesterol in Cord Serum Predict Future Level of Lipoproteins?
Author(s) -
FØNNEBØ V.,
DAHL L. B.,
MOE P. J.,
INGEBRETSEN O. C.
Publication year - 1991
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1991.tb11948.x
Subject(s) - medicine , ldl cholesterol , cholesterol , very low density lipoprotein , endocrinology , lipoprotein
. Lipoproteins were measured in 618 healthy, full‐term newborns. Seventy‐four with a VLD‐LDL‐cholesterol above 1.3 mmol/l (50 mg/dl) at birth and 25 randomly chosen controls with VLDL‐LDL‐cholesterol l.3 mmol/l or below at birth were followed up at age 2. Seventy‐two (52 in the high VLDL‐LDL‐cholesterol group and 20 in the low VLDL‐LDL‐cholesterol group) were followed up at age 13. At age 2 mean total cholesterol was 5.48 mmol/l (SEM 0.10) in the children with a high VLDL‐LDL‐cholesterol at birth, compared to 4.69 mmol/l (SEM 0.17) in the children with a low VLDL‐LDL‐cholesterol at birth ( p < 0.001). A difference was still present at age 13 (4.74 mmol/l; SEM 0.11 versus 4.20 mmol/l; SEM 0.14; p < 0.01). At age 13 apolipoprotein B was 0.74 g/l (SEM 0.02) in the children with a high VLDL‐LDL‐cholesterol at birth, compared to 0.65 g/l (SEM 0.02) in the children with a low VLDL‐LDL‐cholesterol at birth ( p < 0.01). Children with high VLDL‐LDL‐cholesterol at birth might be more liable to high lipoprotein serum levels later in life.