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High Density Lipoprotein Particle Size Distribution in Cord Blood
Author(s) -
KHERKEULIDZE PAATA,
JOHANSSON JAN,
CARLSON LARS A.
Publication year - 1991
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1991.tb11947.x
Subject(s) - medicine , endocrinology , very low density lipoprotein , cord blood , subclass , triglyceride , high density lipoprotein , lipoprotein , cholesterol , immunology , antibody
. Cord blood from 73 full term healthy newborns and blood from adults were analysed for the protein content of high density lipoprotein subclasses separated by gradient gel electrophoresis. Cholesterol and triglyceride concentrations of very low (VLDL), low (LDL) and high (HDL) density lipoproteins were also analysed and newborns had lower concentrations of cholesterol and triglycerides in VLDL, LDL and HDL ( p < 0.001) than adults. The HDL 3c subclass, comprising the smallest particles of the HDL particle spectrum, was the major component for newborns and the minor one for adults and was the only lipoprotein fraction with a higher concentration in cord than in adult blood. No sex differences were present for any of the lipoprotein levels of the newborns. Serum cholesterol concentrations were positively correlated to HDL 2b r = 0.49, p < 0.001) and HD 2a levels (0.42, p < 0.001), correlations confined to the cholesterol contents of HDL ( r = 0.72 and r = 0.67 respectively, both p < 0.001). Serum triglycerides were inversely correlated to HD 2b and HD 2a , levels in male newborns only ( r = 0.38 and r = 0.34 respectively, both p < 0.05). Irrespective of sex, gestational age and birthweight the newborns had 2 typical HDL subclass distributions, characterized by high or low levels of HDL 2b and HDL 2a . The newborns with high HDL 2b and HDL 2a levels also had low VLDL lipid levels and high HDL cholesterol concentrations.