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Single Dose Treatment of Cystitis in Children
Author(s) -
LIDEFELT K.J.,
BOLLGREN I.,
WIMAN A.
Publication year - 1991
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1991.tb11924.x
Subject(s) - medicine , urinary system , urine , trimethoprim , significant difference , cure rate , drug treatment , urology , antibiotics , microbiology and biotechnology , biology
. The efficacy of single dose treatment with trimethoprim compared to a 5‐day course with the same drug was investigated in 100 children, 3–12 years, with isolated episodes of symptomatic non‐febrile urinary tract infection. Cure, defined as sterile urine during the first week after treatment, was achieved in 74 % (37150) in the single dose group compared to 8696 (43/50) in the 5day treatment group. The difference was not statistically significant (χ 2 = 2.25, p =0.134 two‐tailed). The cure rates in relation to P‐fimbriation of the infecting E. coli strains were similar in the two groups. During the 6 month follow‐up, six children in each treatment group had one or more reinfections. Extended studies are needed to conclude if single dose and conventional treatment courses are equally effective.