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Neonatal Sepsis in Pakistan: Presentation and Pathogens
Author(s) -
BHUTTA ZULFIQAR A.,
NAQVI SHEHLA H.,
MUZAFFAR TAHSEEN,
FAROOQUI BADR J.
Publication year - 1991
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1991.tb11916.x
Subject(s) - sepsis , medicine , neonatal sepsis , ampicillin , gentamicin , klebsiella , incidence (geometry) , staphylococcus aureus , pseudomonas aeruginosa , pediatrics , microbiology and biotechnology , antibiotics , escherichia coli , biology , bacteria , gene , biochemistry , physics , genetics , optics
ABSTRACT. The case records of all neonates admitted to the neonatal unit at Aga Khan University Hospital (Karachi) in a 30 month period (Nov. 86April 89) were analysed. Of 60 neonates with confirmed sepsis, 33 (55%) had non‐nosocomial infection (NNC) whereas 27 (45 %) had nosocomial sepsis (NC). The most common organisms causing early‐onset NNC sepsis were Klebsiella species (53%) and Escherichia coli (10%), whereas the organisms causing late‐onset NNC sepsis included Salmonella parathypi (21%), Group A Streptococcus (21%), Escherichia coli (14%) and Pseudomonas species (14%). Klebsiella was the most common organism causing NC sepsis, others being Staphylococcus aureus (15%) and Serratia species (15%). The mortality in NC sepsis, early‐onset and late onset NNC sepsis was 44%, 26% and 43%, respectively. Risk factors associated with NNC sepsis included low birthweight, prematurity and prolonged and complicated deliveries. There was a high incidence of drug resistance to ampicillin and gentamicin among gram‐negative organisms causing sepsis (mean 67 %).