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Urinary C‐peptide Excretion in Obese and Anorectic Children
Author(s) -
WALLENSTEEN M.,
GINSBURG B.E.,
PERSSON B.,
DAHLQUIST G.
Publication year - 1991
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1991.tb11896.x
Subject(s) - anorectic , medicine , excretion , endocrinology , c peptide , insulin , urinary system , anorexia nervosa , obesity , body weight , eating disorders , psychiatry
. To assess the total insulin secretion in children in different nutritional states we have analysed the 24 h urinary C‐peptide excretion in 32 obese children (16 boys and 16 girls) 8–15 years of age as well as in 7 girls with anorexia nervosa 11–16 years of age. Obese children had a median urinary C‐peptide excretion rate of 0.27 nmol/kg/24 h, which was not different from that of a group of normal‐weight children. In the group of anorectic girls, on the other hand, the median value 0.47 nmol/kg/24 h was significantly ( p <0.05) higher than for normal‐weight girls of the same age (median = 0.26 nmol/kg/24 h). These results indicate that in obese children insulin secretion, measured as the 24 h urinary C‐peptide excretion per kg body weight, is the same as in normal‐weight children. Total insulin secretion is consequently increased. In anorexia nervosa, on the other hand, the higher C‐peptide excretion per kg body weight compared with normal‐weight children, indicates that insulin secretion is increased in relation to body weight.