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Isolated ACTH Deficiency with Absent Response to Corticotrophin‐Releasing Factor—41: Evidence for a Primary Pituitary Defect
Author(s) -
MURCH S. H.,
CARTER E. P.,
TSAGARAKIS S.,
GROSSMAN A.,
SAVAGE M. O.
Publication year - 1991
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1991.tb11845.x
Subject(s) - medicine , endocrinology , adrenocorticotrophic hormone , acth secretion , adrenocorticotropic hormone , secretion , hormone
. An 8‐year‐old girl presenting in hypoglycaemic coma was shown to have isolated deficiency of adrenocorticotrophic hormone (ACTH) secretion. Failure to secrete ACTH in response to intravenous administration of synthetic ovine corticotrophin‐releasing factor (CRF‐41) suggests that this disorder was due to a primary pituitary defect, rather than of hypothalamic origin.