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Alloimmune Neonatal Neutropenia in Monozygous Twins: High‐dose Intravenous Gammaglobulin Therapy
Author(s) -
YOSHIDA NAOKO,
SHIKATA TAKUMA,
SUDO SHIGEYUKI,
MATSUMURA ATSUKO,
TSUJII HISASHI,
DOI YASUO,
KINUGASA AKIHIKO,
SAWADA TADASHI,
SAITO KENJI,
MIYAMOTO MITSUKO
Publication year - 1991
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1991.tb11731.x
Subject(s) - medicine , neutropenia , gamma globulin , antibody , immunology , pediatrics , chemotherapy
. An indirect immunofluorescence test using a flow cytometer (FACS420) was useful for detection of antineutrophil antibodies (anti‐NA2 antibodies) in a case of monozygous twins with alloimmune neonatal neutropenia. When high‐dose intravenous gammaglobulin (300 mg/kg for five consecutive days) was given to one twin, the increase in neutrophils was not obvious. Although neutropenia persisted for about three months, no infections were observed in either of the twins.