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Acute Effects of Acetazolamide on Cerebral Blood Flow Velocity and pCO 2 in the Newborn Infant
Author(s) -
COWAN F.,
WHITELAW A.
Publication year - 1991
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1991.tb11724.x
Subject(s) - acetazolamide , medicine , anesthesia , cerebral blood flow , hydrocephalus , intracranial pressure , blood pressure , respiratory rate , heart rate , surgery
. Twelve infants with hydrocephalus were treated with acetazolamide. In those treated intravenously middle cerebral artery blood flow velocity increased by a median of 86% (range 54‐150%). Maximum increase was reached within 2‐20 min. The effect lasted as long as 3.5 hours. Intracranial pressure rose by a median of 4 mmHg (range 0–10 mmHg). There was no significant alteration in blood pressure or heart rate. Respiratory rate increased by approximately 10 breaths/min and the tcpCO 2 , rose by a median 0.2 kPa in infants with normal lungs. In infants treated orally, blood velocity rose by 35‐40% at 60‐80 min with no increase in intracranial pressure. In four infants with lung disease pCO 2 , rose by a median of 2.0 kPa (range 0.6 to 3.4 kPa). Acetazolamide was well tolerated in infants with normal lungs but should be used with caution in the presence of lung disease.