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High‐Dose Growth Hormone Treatment of Non‐Growth Hormone‐Deficient Children: Preliminary Results after 2 Years
Author(s) -
BOUGNÈRES P.F.
Publication year - 1990
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1990.tb11596.x
Subject(s) - medicine , endocrinology , growth hormone , human growth hormone , growth hormone treatment , bone age , hormone , growth hormone deficiency
. The growth response to high‐dose growth hormone (GH) therapy was investigated in 10 short, prepubertal, slowly‐growing children. Two years treatment with recombinant human GH at a dose of 0.3 IU/kg daily 7 days per week resulted in a mean height increase of 19.5 cm (range 17–23 cm). There was a slight but not significant acceleration of bone age maturation. The treatment also induced a sustained increase in insulin secretion without detectable changes in glucose tolerance.