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Effect of Oxandrolone on Growth and Final Height in Turner's Syndrome
Author(s) -
NAERAA R. W.,
NIELSEN J.,
PEDERSEN I. L.,
SØRENSEN K.
Publication year - 1990
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1990.tb11555.x
Subject(s) - oxandrolone , medicine , bone age , turner syndrome , turner's syndrome , growth velocity , body height , gonad , pediatrics , body weight , growth hormone , hormone
. Thirty‐two girls with Turner's syndrome aged 11.5‐16.7 years were treated with oxandrolone (0.125 mg/kg/day). The treatment period was scheduled to 2 years. Height velocity (HV) was expressed in Standard Deviation Scores (SDS), calculated by growth standards for untreated Danish Turner‐girls. For girls with initial bone age below 13 years HV increased significantly from a mean pretreatment value of ‐0.2 SDS (3.1 cm/year) to + 3.5 SDS (5.6 cm/year) in the 1st year of treatment and + 2.1 SDS (4.1 cm/year) in the 2nd year. Mean bone age velocity during treatment was 0.9 year/year. Twenty‐two girls have reached final height. Predictions of their final height were made by three different methods and compared to observed final height. A significant ( p <0.001) improvement in the order of 3‐4 cm was found for girls with initial bone age below 13 years, while girls with higher initial bone age had no height gain ( p >0.3). Side effects were seen in 16% of the girls.