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Concentration of Twelve Plasma Proteins at Birth in Very Low Birthweight and in Term Infants
Author(s) -
POLBERGER STAFFAN K. T.,
FEX GÖRAN,
RÄIHÄ NIELSC. R.
Publication year - 1990
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1990.tb11547.x
Subject(s) - orosomucoid , medicine , transthyretin , apolipoprotein b , retinol binding protein , retinol binding protein 4 , gestational age , endocrinology , transferrin , small for gestational age , albumin , blood proteins , low birth weight , vitamin , retinol , pregnancy , glycoprotein , biochemistry , biology , cholesterol , obesity , insulin resistance , genetics , adipokine
. Plasma samples obtained at birth from 70 very low birth weight (VLBW) infants (gestational age 24 to 34 weeks) and from 20 term infants were analysed for concentrations of 12 different proteins. The plasma concentrations of albumin, transthyretin (TTR), retinol‐binding protein (RBP), vitamin D‐binding protein, apolipoprotein A I, fibronectin, orosomucoid and α 1 ‐antichymotrypsin were significantly lower in the VLBW infants than in the term infants, whereas the values of α‐fetoprotein (AFP) were significantly higher in the VLBW infants. No differences were found between the two groups for apolipoprotein A II, apolipoprotein B and transferrin. Birth asphyxia and sex had no influence on the measured plasma protein concentrations. The plasma concentrations of apolipoprotein A I and A II were significantly lower in small‐forgestational age (SGA), VLBW infants compared with appropriate‐for‐gestational age (AGA), VLBW infants. Possible acute inflammation (defined as raised concentrations of orosomucoid or α 1 ‐antichymotrypsin) was associated with significantly higher values of vitamin D‐binding protein in both VLBW and term infants, suggesting that this protein may act as an acute phase protein in newborn infants.