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Four Years' Experience with Cyclosporin A in Pediatric Kidney Transplantation 1
Author(s) -
HOYER P. F.,
OFFNER G.,
OEMAR B. S.,
BRODEHL J.,
RINGE B.,
PICHLMAYR R.
Publication year - 1990
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1990.tb11526.x
Subject(s) - medicine , prednisolone , renal function , urology , transplantation , nephrotoxicity , kidney transplantation , hyperuricemia , survival rate , kidney , body surface area , regimen , surgery , gastroenterology , uric acid
. From 1982 to 1987 sixty‐three children were treated with cyclosporin A and low dose prednisolone after kidney transplantation. Patient survival rate at 4 years after transplantation was 98.3 %, survival rate of living related grafts 100 % (n = 10), and survival rate of cadaveric grafts 73 % (n = 53). Adequate cyclosporin blood levels were achieved in all children with a dosage regimen related to body surface area. Major concerns during the observation period were the loss of glomerular filtration rate from 51.8 to 40.5 ml/min/1.73 m 2 , a hypertension rate of 77.8 %, and hyperuricemia. Cyclosporin A‐side effects were mild. Infections occurred in 11.1 %. Growth retardation in prepu‐bertal children improved by 0.74 standard deviations of normal height, and in pubertal children by 0.51. We conclude that cyclosporin A treatment in children enables excellent long term graft survival rates with improved growth rehabilitation, however, the prevention of the cyclosporin associated nephrotoxicity and hypertension remains the major problem.