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Saethre‐Chotzen Syndrome Associated with Defective Neutrophil Chemotaxis
Author(s) -
ETZIONI A.,
OBEDEANU N.,
BENDERLY A.,
GERSHONIBARUCH R.
Publication year - 1990
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1990.tb11477.x
Subject(s) - leukocytosis , medicine , chemotaxis , motility , granulocyte , neutrophile , immunology , inflammation , receptor , biology , microbiology and biotechnology
.An 11‐month‐old male infant with Saethre‐Chotzen syndrome and recurrent respiratory infections is described. Persistent extremely high leukocytosis warranted evaluation of neutrophil functions. It was found that the opsonophagocytic activity was normal, but neutrophil chemotaxis was markedly decreased. Further studies pointed to an intracellular neutrophil defect causing this motility dysfunction.