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Renal Consequences of Immobilisation in Children with Fractured Femurs
Author(s) -
ANDREWS P. IAN,
ROSENBERG ANDREW R.
Publication year - 1990
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1990.tb11462.x
Subject(s) - medicine , hypercalciuria , renal function , osmole , creatinine , urine , urine osmolality , calcium , urinary system , urology , urinary calcium , kidney , endocrinology
.Parameters of renal function and calcium homeostasis were studied in 8 children, immobilised for 5‐9 weeks with fractured femurs, weekly during immobilisation and fourth weekly following mobilisation until all parameters returned to normal. During immobilisation 1 patient became hypercalcaemic, but all showed an increase in serum calcium and all developed hypercalciuria. During immobilisation all showed diminished urine osomolality after a 12‐hour fast (mean 591·133 mOsm/kg) which improved 4‐39 weeks after mobilisation (mean 973·87 mOsm/kg). Serum creatinine, urinary beta‐2‐microglobulin and renal ultrasound appearances were all normal. An inverse relationship, R= ‐0.70, was demonstrated between serum calcium and fasting urine osmolality during immobilisation. Three patients showed diminished urinary concentrating ability beyond 4 weeks after mobilisation. For 1 patient this defect persisted for 8 months and glomerular filtration rate was diminished 9 months after mobilisation, raising the possibility of long term renal damage in immobilised patients.