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Potentially Life‐Threatening Cardiac Dysrhythmia in a Child with Selenium Deficiency and Phenylketonuria
Author(s) -
GREEVES L. G.,
CARSON D. J.,
CRAIG B. G.,
McMASTER D.
Publication year - 1990
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1990.tb11423.x
Subject(s) - medicine , selenium deficiency , selenium , tachycardia , pediatrics , etiology , glutathione peroxidase , endocrinology , cardiology , oxidative stress , catalase , materials science , metallurgy
. Selenium deficiency is a frequent finding in children with phenylketonuria (PKU) receiving dietary treatment. We report the occurrence of episodic ventricular tachycardia in a 9‐month‐old infant with PKU. Serum selenium (Se), 0.13 μmol/1 (normal range 0.28–1.12 μmol/1, mean ± 2 SD), and whole blood glutathione peroxidase (GSHPX), 16 U/g Hb (normal range 19.5–34.3 U/g Hb, mean ± 2 SD), were low. Auscultation of cardiac rhythm is recommended during the routine follow‐up of young children with PKU. Se deficiency should be considered in the aetiology of a dysrhythmia and corrected with Se supplementation.