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Plasma Amino Acids in Term Neonates and Infants with Phenylketonuria before and after Institution of the Diet
Author(s) -
GERDES A.M.,
NIELSEN J. B.,
LOU H.,
GÜTTLER F.
Publication year - 1990
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1990.tb11332.x
Subject(s) - valine , postprandial , phenylalanine , medicine , isoleucine , leucine , amino acid , endocrinology , tyrosine , meal , plasma concentration , phenylketonurias , biochemistry , chemistry , insulin
.The plasma amino acid concentrations were measured in 12 neonates with phenylketonuria (PKU). Blood samples were taken when fasting and two hours after a meal. The individual amino acid concentrations, the glycine/valine ratios, and the total amino acid concentrations were mutually compared and also compared to reference intervals. When the diet was instituted and plasma phenylalanine decreased, we observed a normalization of the postprandial response of isoleucine, leucine, tyrosine, and valine.