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In Vitro Evidence for Impaired Cellular Immune Responsiveness in Children with Chronic Renal Failure
Author(s) -
MANCA F.,
PERFUMO F.,
KUNKL A.,
COSTANTINI M.,
GUSMANO R.
Publication year - 1989
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1989.tb17943.x
Subject(s) - medicine , immune system , chronic renal failure , hemodialysis , peritoneal dialysis , lymphocyte , population , dialysis , in vitro , cellular immunity , immunology , biochemistry , chemistry , environmental health
. We used mixed lymphocyte culture (MLC) as an assay to evaluate in vitro the cellular immune functions of children with chronic renal insufficiency (CRT) or with chronic renal failure (CRF). The proliferative response of lymphocytes from both groups of patients was significantly reduced as compared to the response of control individuals. In addition, the proliferative response of CRF patients treated with hemodialysis was significantly lower than the response of continuous ambulatorial peritoneal dialysis (CAPD) patients. These data confirm that a marked depression of the cellular immune response is detectable in a pediatric population, as predicted from data from the literature on the adult renal failure population.