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Urinary Lactic Dehydrogenase Isoenzyme Analysis in Children with Spinal Lesions
Author(s) -
YOKOCHI K.,
UCHIDA T.,
KODAMA K.
Publication year - 1989
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1989.tb17941.x
Subject(s) - medicine , lactic dehydrogenase , urinary system , isozyme , lactic acid , enzyme , biochemistry , bacteria , genetics , biology
. In 48 children with spinal lesions and micturition problems urinary lactic dehydrogenase (LDH) isoenzymes were analyzed. They had higher total LDH activities (716.8 ± 1050.2 nkat/1), isoenzymes V percents (22.2 ± 13.0 %) and isoenzyme V activities (203.4 ± 308.4 nkat/l) than those of healthy children (150.0 ± 83.4 nkat/1,1.9 ± 1.0 %, 5.0 ± 3.3 nkat/1). Many subjects had an isoenzyme V‐dominant LDH isoenzyme pattern. Among 48 subjects the patients with pyuria, bacteriuria or abnormal pyelograms had markedly high total LDH activities, isoenzyme V percents and isoenzyme V activities. The rise in LDH isoenzyme V levels may reflect the renal damage in the patients with neurogenic bladders.