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The Severity of RDS during the First Two Neonatal Days in Relationship to Fluid Intake
Author(s) -
HALLMAN M.
Publication year - 1989
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1989.tb11288.x
Subject(s) - medicine , fluid intake , enteral administration , parenteral nutrition , respiratory system , degree (music) , respiratory failure , pediatrics , physics , acoustics
Hallman, M. (Departments of Paediatrics, University of Helsinki and University of California, Irvine). The severity of RDS during the first two neonatal days in relationship to fluid intake. Acta Paediatr Scand Suppl 360: 93, 1989. There are no generally accepted guidelines regarding the degree of hydration of small preterm infants with RDS. In the present prospective study, liquid intake (intravenous fluids, drugs, and enteral nutrition) during the first 48 h was correlated with the degree of respiratory failure at the age of two days in 120 consecutive, mechanically ventilated, small preterm infants with RDS (GA<30 w, BW< 1750 9). There was a positive linear relationship between the amount of liquids given and the degree of respiratory failure. Multiple regression analysis taking into consideration various perinatal factors revealed that the liquid intake explained the degree of respiratory failure (p < 0.0001). The regression analysis revealed a similar dependence of respiratory failure on the liquid intake in the following groups of infants: GA<27 w (p=0.023); GA 27–30 w (p=0.005); SGA (p=0.104); Non‐SGA (p=0.001); severe preeclampsia (p=0.018); surfactant substitution (p=0.002); liquid intake 127–240 m1/48 h (p < 0.006); liquid intake 240430 mU48 h (p < 0.047). The present results demonstrate the need to re‐evaluate the optimal needs of hydration among infants with RDS during the very early neonatal period.