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Effect of P a CO 2 and Haemoglobin Concentration on Day to Day Variation of CBF in Preterm Neonates
Author(s) -
PRYDS O.,
GREISEN G.
Publication year - 1989
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1989.tb11279.x
Subject(s) - medicine , gestational age , anesthesia , neonatology , blood pressure , respiratory distress , oxygen , arterial oxygen tension , carbon dioxide , hemodynamics , respiratory system , pregnancy , lung , chemistry , genetics , organic chemistry , biology
Pryds, O. and Greisen, G. (Department of Neonatology, Rigshospitalet, Copenhagen, Denmark). Effect of P a CO 2 and haemoglobin concentration on day to day variation of CBF in preterm neonates. Acta Paediatr Scand, Suppl 360: 33, 1989. The CBF was measured on the first three days of life in 22 mechanically ventilated, preterm neonates (mean gestational age 29.5 weeks) with simultaneous recordings of arterial carbon dioxide tension (P a CO 2 ), arterial oxygen tension (P a O 2 ), haemoglobin concentration (Hgb), haemoglobin oxygen saturation and mean arterial blood pressure (MABP). CBF ± tended to increase slightly with age. The intra‐individual variation of CBF ± was positively related to changes in P a CO 2 (p=0.0004) and inversely related to changes in Hgb (p=0.029). Neither P a O 2 nor MABP achieved a significant relation to changes in CBF ± Thus, the mean CBF ±‐CO 2 reactivity was calculated to 22.1 % per kPa whereas CBF increased by a mean of 11.9% per mM decrease of Hgb thereby providing a constant oxygen delivery to the brain. It is concluded that P a CO 2 and Hgb have the expected effect on CBF ± in preterm neonates even during respiratory distress shortly after birth.